Enantioselective Disposition of MDMA and its Metabolites

Enantioselective Disposition of MDMA and its Metabolites Presentation Amphetamine-type energizers (ATS) are a gathering of medications, generally engineered in inception, that are fundamentally gotten from ÃŽ ²-phenethylamine (Figure 1). Amphetamine (AMP, Speed) was at first incorporated in Berlin in 1887 as 1-methyl-2-phenethylamine. It was the first of a few synthetic concoctions, including methamphetamine (MET, Ice) and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), which have comparative structures and natural properties, and are alluded to on the whole as amphetamines (Cody, 2005). Since 1887, amphetamine was believed to be a human development (Berman et al., 2009), yet the compound was found in 1997, alongside methamphetamine, nicotine and mescaline, inside two types of Texas acacia shrubberies (Clement, Goff and Forbes, 1998). AMP and MET are most generally manhandled drugs. They have hilter kilter focus and exists as one of the two potential enantiomers (see Figure 2) (Cody, 2005). In endeavor to keep up anorexic action while restricting bothersome reactions, replacements have been made to amphetamine and methamphetamine. Others have been made to upgrade the stimulatory action or to maintain a strategic distance from lawful limitations on the production and utilization of the medications (Cody, 2005). The related gatherings of amphetamine subordinates are appeared in Figures 3 and 4. Figure 5 shows another gathering of antecedent medications that is utilized by the body into AMP and MET. Organization and neurotoxicity of amphetamines Amphetamines are for the most part regulated as oral cases. This course brings about a continuous increment in tranquilize fixation, which tops in around an hour and keeps up viable medication levels for 8 †12 hours. Amphetamines can likewise be infused into the dissemination (Parrott et al., 2004). Amphetamines promptly cross the blood-mind obstruction to arrive at the locales (Berman et al., 2009) of activity in the cerebrum. The intense organization of amphetamines produce a wide scope of portion subordinate social changes, including expanded excitement or alertness, anorexia, hyperactivity, perseverative developments, and, specifically, a condition of pleasurable effect, delight, and rapture, which can prompt the maltreatment of the medication (Berman, 2009). This makes amphetamines be related with demonstrations of brutality. Intense medication abusers will create resilience, where a similar portion of medication has reducing physiological and mental impacts. They have to b uild their measurement on the off chance that they wish to produce a similar quality of impact. Cross-resistance will likewise happen as resilience to one medication influences another medication with comparable neurochemical profile. Thus, tranquilize abusers will look for another class of medication and become polydrug clients (Parrott et al., 2004). Constant medication abusers typically take in amphetamines through infusion or smoking ice amphetamines. These abusers endure numerous medical issues and a decreased future. They are increasingly defenseless to HIV (human immunodeficiency infection), AIDS (gained insusceptibility lack disorder) and SIDS (abrupt newborn child passing condition) (Parrott at al., 2004). Clinical employments As per the Convention on Psychotropic Substances of 1971, amphetamines are enrolled as opiate mixes in the List of psychotropic substances under global control. The rundown is set up by the International Narcotics Control Board. These mixes are denied to be imported and sent out in nations like Japan, Nigeria, Pakistan, Thailand and so forth (International Narcotics Control Board, 2003). Amphetamines and related mixes are clinically utilized for narcolepsy (unexpected day-time beginning rest) and Attention Deficit Hyperactivity Disorder (ADHD) in small kids. It was in the past utilized as a present moment thinning operator, as an energizer and to help athletic execution (Parrott et al., 2004). 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA, ECSTASY) History of MDMA misuse MDMA, otherwise called joy, ETC, or Adam, is one of the most usually mishandled amphetamine subsidiaries that was re-orchestrated by Alexander Shulgin during his examination profession at the Dow Chemical Company in 1970s. Before long MDMA was being blended in unlawful labs, and got well known as recreational medication from that point forward. As MDMA doesn't have any clinical/clinical use, it is planned as Class I unlawful medication by the American Drug Enforcement Agency in 1985 (Parrott et al., 2005). Additionally, MDMA other ring-subbed phenylethylamines were conventionally grouped under the Misuse of Drugs Act as Class A medications, in United Kingdom (Wikipedia, 2009). Substance Properties of MDMA The methylenedioxy analogs of amphetamine (see Figure 3) are arrangement of mixes alluded to creator drugs. They incorporate methylenedioxyamphetamine (MDA), methylenedioxyethylamphetamine (MDEA) and MDMA (Hensley and Cody, 1999). The blend of N-alkyl-MDA subordinates just delivers ( ±) racemic blends. As an outcomes, just racemic types of (cases, free powder or tablets) the mixes are sold in the unlawful market and mishandled (Matsushima, Nagai and Kamiyama, 1998; Fallon et al., 1999). MDMA is chiral, having two enantiomers, S-(+)- MDMA and R-(- )- MDMA (see Figure 6), with S-(+)- MDMA is more intense than R-(- )- MDMA (Lyon, Glannon and Titeller, 1986; Shulgin 1986). The essential structure of MDMA is ?- phenylisopropylamine gathering (see Figure 6), with a methylenedioxy bunch framing a 5-membered ring including C-3 and C-4 of the benzene ring (Cho and Segal, 1994). The experimental recipe of MDMA is C11H15NO2 (Shulgin, 1986). MDMA is a phenylisopopylamine gotten from safrole, sweet-smelling oil found in sassafras, nutmeg, and different plants. The methyl bunch on ÃŽ ±-carbon (R2) (see Figure 6) of MDMA gives protection from oxidative deamination of this compound and, along these lines, expanded its metabolic half-life (Cho and Segal, 1994). As per Cone and his associate Huestis (2009), S(+) isomer of MDMA is liable for its psychostimulant and empathic impacts and the R(- ) isomer for its psychedelic properties. Take-up, assimilation, digestion and disposal of MDMA in human body MDMA is typically planned in tablets of its racemate (1:1 blend of its enantiomers) in dosages running from 50 to 200 mg (Pizarro et al., 2004), which is most normally sold in clusters of 3â€5 for ?10 (Wikipedia, 2009). MDMA powder is likewise found in the market at a more significant expense, showing that it has higher immaculateness. MDMA powder isn't typically insufflated (grunted) as it causes wheezing, agony and nosebleeds. MDMA can't be smoked and is once in a while infused intravenously (AMCD, 2008). MDMA is retained into the circulation systems and conveyed in body. After death examination by Letter et al. (2002) shows that MDMA is conveyed in heart muscle, the two lungs, liver, the two kidneys, spleen, the four cerebrum flaps, cerebellum and brainstem, fat tissue, serum, vitreous silliness, pee, hair and bile upon organization. Fast conveyance of MDMA in body is essentially because of its fundamental property of pKa around 9.9 and low plasma protein authoritative, MDMA can diffuse across organic frameworks that is more acidic than blood (Pichini, 2005). After an oral organization of MDMA, the plasma fixation tops in inside 1.5 to 2 hours (Cone and Huestis, 2009). MDMA is used by numerous pathways (see Figure 7), fundamentally including N-demethylation and O-demethylenation. The proteins associated with the pathway are a gathering of cytochrome P450 isoenzymes, including CYP1A2, CYP3A4, and CYP2B6. Right off the bat, MDMA is O-demethylenated to 3,4-dihydroxymethamphetamine (HHMA) trailed by O-methylation to 4-hydroxy-3-methoxymethamphetamine (HMMA). The proteins engaged with the metabolic procedure are CYP2D6 and catechol-methyltransferase individually. At a lower rate, MDMA is N-demethylated to 3,4-methylenedioxyamphetamine (MDA) (a response directed by CYP2B6), which is additionally utilized to the catechol middle of the road (3,4-dihydroxyamphetamine) lastly O-methylated to 4-hydroxy-3-methoxyamphetamine (HMA). In the responses, the ÃŽ ±-carbon liable for stereochemical properties of MDMA isn't influenced and all the metabolites are chiral intensifies that might be introduced as a blend of their enantiomers. Notwithstanding these significant aggravates, some other minor metabolites got from the movement of monoamine oxidase on the amine buildup are additionally framed (Kolbrich et al., 2008; Pizarro et al., 2004). N-demethylation of MDMA yields 3,4-methylenedioxyamphetamine (MDA), a functioning metabolite showing comparable pharmacological properties as the parent medicate. A further O-demethylenation of MDA produces 3,4-dihydroxyamphetamine (HHA) which is fundamentally directed by CYP2D6. Extra metabolites are shaped by O-methylation of HHMA to 4-hydroxy-3-methoxymethamphetamine (HMMA) and of HHA to 4-hydroxy-3-methoxyamphetamine (HMA), deamination, and conjugation (Cone and Huestis, 2009). The metabolic pathway mostly occurs in the liver. A few people with diminished CYP2D6 shows lower metabolic pace of MDMA and in this way are increasingly helpless to MDMA harmfulness (ODonohoe et al., 1998; Schwab et al., 1999). Physiological and mental impacts of MDMA Berman et al. (2009), Hensley and Cody (1999) and Piper (2008) detailed an expanded sharpness and happiness, expanded pulse, circulatory strain, breath and internal heat endless supply of MDMA. Joined Nation Office on Drugs and Crime (2006) passes on that incessant amphetamines misuse causes tumult, tremors, hypertension, memory misfortune, visualizations, insane scenes, distrustful dreams, and fierce conduct. Withdrawal from high dosages of amphetamine-type energizers (ATS) could bring about extreme sadness. MDMA disables the temperature control by nerve center. This makes MDMA clients kick the bucket of hyperthermia (Piper, 2008) and some pass on from hyponatraemia, for example the weakening of blood because of unnecessary liquids taken to check heat weariness (Parrott et al., 2004). Neurotoxicity of MDMA Nichols (1986) and Vollenweider et al. (1998) sort MDMA as entactogens, a s

A report on the Cultural Afternoon held at the IPBA’s auditorium Free Essays

Keep going Thursday on the July 24th, 2003, a Cultural Afternoon was being held at the IPBA’s theater. It was sorted out by the MTCP members and the B. Ed. We will compose a custom paper test on A report on the Cultural Afternoon held at the IPBA’s theater or on the other hand any comparable subject just for you Request Now TESL companion 1 understudies. The topic for the Cultural Afternoon is Unity In Diversity. Solidarity In Diversity is a sonnet composed by the MLCP member from Papua New Guinea. The evening was directed by two of the B. Ed. TESL understudies. They directed the occasion quite well. From that point onward, Mr. Mahmud from Turkey was called upon to recount a petition. After he had wrapped up the supplication, the occasion proceeded with the main execution by the B. Ed. TESL understudies. They introduced an arrangement of the Malay Traditional Dance. The move was arranged flawlessly and the artists moved effortlessly. The exceptional thing about this social evening was the manner in which the coordinator changed the conductors. The following conductors were the members from Tunisia and Gambia. The manner in which they directed the evening was fascinating. After they had presented themselves, they called upon members from Krygystan, Miss Ainur. She sang a tune called Mahabbad, which means love. Despite the fact that the crowd couldn't get her, yet the message of the melody were well deciphered. At that point, all the MTCP members were invited to join the conductors on the phase to presented themselves. All the members were presenting themselves with various ways. Some of them made a few jokes, holding their conventional banner, etc. There were 26 members that day who has originated from various nations, for example, Zimbabwe, Croatia, Tunisia, Gambia, Bosnia, Thailand and different nations. From that point forward, Mr. Bernard from Bosnia introduced his presentation by singing a tune utilizing his own language. Followed by named and Ameir from Bosnia. They appeared and clarified about a banner of the Bosnian Movie, which had won oscars grant 2000/2. The film title is ‘No Man’s Land’ has won the honor for Best Foreign Language. From that point forward, they sang a Bosnian society tune. In the wake of changing conductors by and by, B. Ed. TESL understudies played out their Kung Fu exhibitions. After the Kung Fu appear, a member from Turkey sang a superb tune. The crowds gave her enormous applauds in light of the fact that she had sang the melody well even without the ambient sounds. All the crowds had given full consideration on the phase to see the conventional outfits appear from different nations. All the members wore their own customary outfits and did a few clarifications on the ensembles. Subsequent to viewing the bright design appear, the crowds were extremely astounded to watch the Indian move that was driven by our B. Ed. TESL understudy, Danielli Devi. The move was loudly cheerful with enthusiastic artists and well known Bollywood tune played. From that point onward, the Cultural Afternoon proceeded with the exhibitions by the MTCP members. The members from Sri Lanka sang a melody. The melody additionally an affection tune. From that point onward, the East Timur member did a customary move. She wore her conventional ensembles and a gong. She thumped the gong utilizing a few rhymes and afterward moved followed the rhyme. It was far not the same as other MTCP participant’s exhibitions. From that point onward, a member from Turkey likewise sang an affection melody. Another intriguing exhibition was from the Thailand members. They appeared and encouraged us the correct route in welcome. Their presentation is very helpful for us. From that point onward, the Cambodian members moved when their melody was played. Next execution was from Gambia. He sang his national hymn. The crowds ascended to show regard. The most holding up execution was Para-para Sakura Dance. The B. ED. TESL understudies played out this move. They moved nimbly with many amazing advances. The artists were extremely vigorous and boisterously joyful with their red and pink outfits. All the crowds felt revive in the wake of watching this fiery move. Finally, before the Cultural Afternoon finished, the member from Papua New Guinea presented her sonnet entitled ‘Unity In Diversity’. She all around composed the sonnet. The occasion finished when the conductors proclaimed it was shut. The most effective method to refer to A report on the Cultural Afternoon held at the IPBA’s amphitheater, Papers

The Medias Influence on Eating Disorders

The Media's Influence on Eating Disorders Eating Disorders Print The Medias Influence on Eating Disorders By Susan Cowden, MS facebook linkedin Susan Cowden is a licensed marriage and family therapist and a member of the Academy for Eating Disorders. Learn about our editorial policy Susan Cowden, MS Medically reviewed by Medically reviewed by Steven Gans, MD on August 05, 2016 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Updated on August 27, 2019 More in Eating Disorders Symptoms Treatment Diagnosis Awareness and Prevention If you pay attention to mainstream media, youll undoubtedly find that it often sends a strong message that thin, white, and able bodies are the most desirable and, by extension, that all other bodies have less value. Furthermore, beauty products and diets  are marketed, especially to women, as a way to achieve that so-called desired body. In fact, millions of dollars are spent each year marketing both the beauty and diet industries. This results in a constant barrage of images and messages discouraging men and women from being satisfied with their bodies and encouraging them to change their appearance. How does this messaging affect us? Does it cause or influence eating disorders or other similar dangerous behaviors? The answer is complicated. Research supports the idea that there is a familial, genetic component to eating disorders, but it also indicates that the current socio-cultural environment (which includes the media) plays a role in the development and maintenance of eating disorders. It can certainly be harder to recover from an eating disorder when youre faced with constant media images of very thin people or television shows putting people with larger bodies through intense and sometimes torturous routines in order to lose weight. Study Shows TV Has an Influence on Eating Disorders In 2002, a landmark study was published that assessed the influence of television on eating attitudes and behaviors in Fijian girls. The Fiji islands didnt have access to mainstream television prior to 1995, which gave researchers the chance to truly see how attitudes and behaviors changed once TV arrived. Fijian culture traditionally values curvy bodies. Large appetites are encouraged, while dieting is discouraged. In 1995, adolescent girls were surveyed and it was found that virtually none of them reported dieting in order to lose weight. Additionally, none of the girls reported self-induced vomiting. In 1998, after three years of exposure to Western television, the survey was repeated with the following results: 11.3% indicated self-induced vomiting to control weight69% reported dieting74% reported feeling too big or fat at least some of the time Girls who lived in a house with a television set were three times more likely to experience disordered eating behaviors than those who didnt. Although it is difficult to generalize these results with regard to all other cultures, the study shows that the media (and television in particular) does have an impact on  body image  and eating behaviors. A follow-up study showed that just having friends who watched television could also increase the risk of eating disorder symptoms. Impact of the Internet and Social Media on Eating Disorders Recent years have seen a proliferation of online images known as thinspiration or thinspo. These are primarily found on  pro-eating disorder websites, although they have been popping up on more mainstream sites as well. Research has shown that viewing these images results in a lowered caloric intake and lower self-esteem. There have also been studies  that indicate that using social media sites, such as  Facebook, puts adolescent girls and women at greater risk for disordered eating. It also places everyone at risk of feeling poorly about themselves and dissatisfied with their bodies.? More research is needed in this area, but it is reasonable to believe that frequent use of social media does affect how a person views themselves. Fashion Magazines Impact on Eating Disorders The majority of research in print media and eating disorders has centered around fashion magazines, as they regularly feature photographs of unrealistically thin models that have often been extensively Photoshopped. Research has shown that adolescent girls who regularly read and look at fashion magazines are two to three times more likely to diet to lose weight because of an article. One study, which surveyed girls from grades 5â€"12, found that: 69% of girls report that magazine pictures influence their idea of the perfect body shape47% report wanting to lose weight because of magazine pictures A Word From Verywell Research shows that high levels of concern about weight, dieting, and a desire to look like models or celebrities are all indicators for an increased risk for all eating disorders. While its nearly impossible to avoid media influence with todays technology, media literacy education can provide the tools needed to critically evaluate and question the messages we receive and mitigate their negative effects.

Brave New World By Aldous Huxley - 1399 Words

For many people, the term â€Å"designer babies† sounds like something that could only exist in the novel, Brave New World by Aldous Huxley. But, science has now advanced to the point where faulty genes can now be singled out, discarded, and replaced with more favorable ones. Just like the 16,012 babies manufactured in the Hatchery and Conditioning Centre in Brave New World, human embryos can be selected for fertilization based on their genes. This is done through the processes of in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD). This involves removing mature egg cells from a woman and fertilizing it with male sperm outside of the body. The embryos are then analyzed for abnormalities and mutations in the deoxyribonucleic acid (DNA). The healthiest embryos are then implanted back into the woman’s uterus for regular gestation (Yount). The development of these techniques originated from the Human Genome Project initiated by the United States governm ent in 1988 (Siegel-Itzkovich). Although established initially with the purpose of selecting healthy embryos free of disease, the same techniques can be applied to select genes that code for traits such as intelligence, strength, and beauty. IVF and PGD are useful techniques but should only be used for medical purposes, not for selecting the embryos of perfect children. IVF and PGD can lower the pressure on a family when having a child by guaranteeing the birth of a healthy baby. This is because they are used toShow MoreRelatedA Brave New World by Aldous Huxley668 Words   |  3 PagesIn Brave New World, there are similarities that have a deeper meaning that we can understand. There are personal effects in Aldous Huxley life that contribute to what he has written in the book. Aldous Huxley throughout his life have seen, done, and events have happened to him, just like all of us, but he has expressed it in his book. So when Aldous wrote the he had so many ideas. I have read the book; it’s notRead MoreBrave New World by Aldous Huxley811 Words   |  3 Pages Brave New World is based around characters who gave up the right of freedom for happiness; characters who ignored the truth so that they could live in a utopian civilization. The deceiving happiness was a constant reminder throughout the book. Almost every character in Brave New World did whatever they could to avoid facing the truth about their own situations. In this society, happiness is not compatible with the truth because the World State believes that happiness was at the expense of theRead MoreBrave New World By Aldous Huxley1525 Words   |  7 PagesA Brave New Feminist The novel Brave New World written by Aldous Huxley in 1932 is known for its social satire, utopian values, and unusual standpoints on stereotypical gender roles. In this time where futuristic technology has completely taken over, and men and women are given the same opportunities for everything, â€Å"the genders appear equal within the social order; both men and women work at the same jobs, have equal choice in sexual partners, and participate in the same leisure pursuits† (MarchRead MoreA Brave New World by Aldous Huxley664 Words   |  3 Pagesfor the fact being in the future and in the past time has changed and many differences were made. In his Dystopian Society Huxley portrays masses of niches where the government produces clones for specific reasons. Huxley decides throughout Brave New World that cloning humans is unethical. He then becomes in contact with the society’s most powerful Alphas and Betas clones. Huxley suggest in BNW that lower class groups in clo ning humans to act like servants to terrorize them into working hard conditionsRead MoreA Brave New World by Aldous Huxley1189 Words   |  5 Pages In the world of sex, drugs, and baby cloning you are going to be in many situations where you feel like the world we live in should be different. In the story Brave New World, they had sex with multiple partners along with a very bad use of drugs. It is weird that Aldous Huxley wrote this book in 1931 about the world he was living in during that time and how it is similar to the world we live in today. Nowadays, drugs are still being used and people are still engaging in sexual encounters withRead MoreBrave New World By Aldous Huxley968 Words   |  4 PagesAldous Huxley’s utopia in Brave New World foreshadowed and illuminated the complications within modern day society. Upon its release, the narrative became widely banned all over the United States due to the unorthodox thoughts and actions of multiple characters in it. Early readers, as well as modern day audiences, feared and rejected the ideals that Huxley incorporated into his perfect society; however, our society today is heading towards the dark paths the older generations desired to avoid. Read MoreA Brave New World by Aldous Huxley895 Words   |  4 Pagesthe novel Brave New World, Aldous Huxley tells of a society where everyone is the same but, compared to t oday’s society, everything is different. Huxley tells of a world where everything that happens or takes place is because of one’s own desire and nothing more. The hero in the novel, a â€Å"savage† named John, is Huxley’s main focal point. It is through his eyes and mind that the reader sees what’s going on. Now when I read this novel, I began to think, â€Å"Could this perfect, conformed world actuallyRead MoreA Brave New World by Aldous Huxley1684 Words   |  7 Pagesimperfect world and is usually only a hopeful dream. These types of worlds can greatly be described in detail through the world of science fiction. Aldous Huxley was an English writer who lived during a time when war and chaos were engulfing the world. His works reflect his view and thoughts on a dystopia, which is a false utopia, and describes what could occur in possible governments of the world. The ability to understand and dive into the thoughts of the author is what make s world literatureRead MoreA Brave New World by Aldous Huxley614 Words   |  2 Pagesthem truly happy. What if someone were to tell you that what you thought was true happiness was all an illusion. In a Brave New World by Aldous Huxley people in the world state are conditioned and drugged up by soma to not experience true happiness. In a world that is perfect, human beings do not have to depend on drugs to keep our world in balance. In a Brave New World by Aldous Huxley there is always a perfect drug called soma that keeps everyone happy, which they have based their society on. ThisRead MoreA Brave New World by Aldous Huxley948 Words   |  4 PagesWelcome to a world were â€Å"Brave† is not just a word; It has a true meaning. This is a story were everything as you know it, doesn’t seem to be right and will completely change your way of thinking. When this story was written, life was very harsh for many people†¦.Mostly for the author who wrote â€Å"Brave New World† During this time (1930s) they didn’t have much sexual content Living The Future Of The Past In The Present†¦.. In the air; But Aldous made a future full of sex for them and we are the

The Federal Bureau Of Investigation - 1697 Words

Research Paper The real question here is, What kind of world do you want to live in? According to an article in Fortune Magazine one person said, â€Å"The Federal Bureau Of Investigation is creating a world where citizens rely on Apple to defend their rights, rather than the other way around.† A world where national security trumps personal privacy or would you rather live in a world where we have both national security and personal privacy. Amy Goodman from Democracy Now said in a segment, â€Å"In December, Farook and his wife killed 14 and injured 22 others in San Bernardino. The two were killed in a shootout with police.† The issue is that the agency has been unsuccessful in accessing the data in the phone, an iPhone 5C. We all remember when more than 100 A-listers were targeted in a colossal hack and Apple was under fire for â€Å"breaches† in the cloud. This was iOS 7 and the hackers targeted individual accounts. Since then Apple has released iOS 8 and iOS 9. Any device running iOS 8 or later has built-in security measures such as encrypted data tied to your passcode, push notifications when someone tries to restore your iCloud data on a different device, tries to change your iCloud password instead of an email as well as an auto-erase feature that erases all data on the photo when there 10 incorrect passcode tries and a delay between passcode tries. Therefore, the FBI cannot enter the iPhone’s data by brute force. The FBI believes that there might be some importantShow MoreRelatedThe Federal Bureau Of Investigation Essay885 Words   |  4 PagesThe Federal Bureau of Investigation (FBI) originated on July 26, 1908, as the Bureau of Investigation by U.S. Attorney General Charles Bonaparte. In 1935 the name was changed to the Federal Bureau of Investigation. Director Mueller reconstructed the FBI to support the changes the Bureau made â€Å"to meet newly articulated strategic priorities† from 2001 to 2013 (Brie f History).On September 4, 2013, James B. Comey was sworn in as the seventh Director of the FBI. The main focus of the Federal Bureau ofRead MoreThe Federal Bureau Of Investigation890 Words   |  4 PagesThe Federal Bureau of Investigation (FBI) originated on July 26, 1908, as the Bureau of Investigation by U.S. Attorney General Charles Bonaparte. In 1935 the name was changed to the Federal Bureau of Investigation. Director Mueller reconstructed the FBI to support the changes the Bureau made â€Å"to meet newly articulated strategic priorities† from 2001 to 2013 (Brief History, 2010). On September 4, 2013, James B. Comey was sworn in as the seventh Director of the FBI. The main focus of the Federal BureauRead MoreThe Federal Bureau Of Investigation921 Words   |  4 Pagesthe United States government, specifically the Federal Bureau of Investigation was in a dispute with the technology company Apple. The FBI seized the iPhone of Syed Farook who along with his wife Tasfeen Malik killed 14 people and injured 22. Farook and his wife were then killed in a shootout with the police. However, the FBI could not bypass the security code that Farook placed on his phone, and access information within the device. Therefore, the bureau requested that Apple create a backdoor whichRead MoreThe Federal Bureau Of Investigations1777 Words   |  8 PagesMatt Fox Mr. Huggins U.S. History 21 November, 2014 The FBI The Federal Bureau of Investigations was initially a group of secret agents created in 1908 by Attorney General Charles Bonaparte. Bonaparte created the FBI under direction of 26th president, Theodore Roosevelt. For the first couple of years, the amount of federal crimes was very low. The Bureau spent most of their time investigating things such as national banking, bankruptcy, naturalization, antitrust, peonage, and land fraud. In JuneRead MoreFederal Bureau Of Investigation Agent Essay922 Words   |  4 Pagesexciting career, because of the endless possibility of helping the world get better in any kind of way . The research will describe the career of Federal Bureau of Investigation , what is required to become a Federal Bureau of Investigation agent a successful career and the impact this career has on has on society. The Federal Bureau of Investigation hires an agent to act as the lead investigators in the United States. The duty of an FBI is to guard the United States from Terrorists and ForeignRead MoreFederal Bureau Of Investigation Agent Essay907 Words   |  4 PagesFederal Bureau of Investigation (FBI Agent) Associate Dean once said â€Å"It just dispelled all of the bad things I’d ever heard about the FBI†¦ that the FBI was sneaky and out to get people.† The career of the FBI is a remarkable and exciting career, because of the endless possibility of helping the world get better in any kind of way . The research will describe the career of Federal Bureau of Investigation , what is required to become a Federal Bureau of Investigation agent a successful career andRead MoreEssay on The Federal Bureau of Investigation1992 Words   |  8 PagesThe Federal Bureau of Investigation The agency now known as the Federal Bureau of Investigation (FBI) was founded in 1908 when Attorney General Charles J. Bonaparte appointed an unnamed force of Special Agents to be the investigative force of the Department of Justice (DOJ). Prior to that time, DOJ borrowed Agents from the U.S. Secret Service to investigate violations of federal criminal laws within its jurisdiction. By order of Attorney General George W. Wickersham, the Special Agent forceRead MoreFederal Bureau Of Investigation ( Fbi ) Essay903 Words   |  4 PagesThe Federal Bureau of Investigation (FBI) is the local insight and security administration of the United States, which all the while serves as the country s prime government law implementation organization. Working under the ward of the U.S. Bureau of Justice, the FBI is simultaneously an individual from the U.S. Intelligence Community and reports to both the Attorney General and the Director of National Intelligence. A main U.S. counterterrorism, counterintelligence, and criminal investigativeRead MoreFederal Bureau Of Investigation : Special Agent1656 Words   |  7 PagesThe Federal Bureau of Investigation: Special Agent The Federal Bureau of Investigation is a federally-funded agency that was founded in 1908 by Attorney General Charles Bonaparte during the presidency of Theodore Roosevelt. The FBI, formerly know as the Bureau of Investigation (1909-1935) recruited men with previous law enforcement experience to become a part of this exclusive team that aimed to solve law violations such as bankruptcy, naturalization, antitrust, peonage, and land fraud. The MannRead MoreFederal Bureau Of Investigation And Its Legal Implications854 Words   |  4 PagesFederal Bureau of Investigation takes all cases of alleged terrorist activity seriously, and they thoroughly investigate each case. According to Roth (2014), instead of seeking solely to identify individuals who are actively engaged in criminal conduct, now agents also have deliberately sought to identify individuals who might be willing to aid acts of terrorism, even if they are not currently involved in such activities (p. 981). The vagueness of th e term willing and its legal implications can

Marketing of Financial Services †Georgia Supplemental Free Essays

According to the case Florida seems to be a flourishing prospective market for supplemental insurance. The demographics of the state already show large migration trends resulting in influx of young families coming into the state which is offering them comfort and security with better jobs. According to the 10 year projection of Georgia Supplemental, of the activity in the Florida market, the demand for supplemental insurance is bound to increase. We will write a custom essay sample on Marketing of Financial Services – Georgia Supplemental or any similar topic only for you Order Now This is because of the increasing members in the household in the future years and the fact that most employers in Florida do not provide complete coverage of expenses through insurance. The case depicts the statistics that this particular segment of the market is to grow at 6-7 percent in the next 10 years. Another issue which makes Florida an attractive marked for supplemental insurance policies offered by Georgia is that sideline expenses are often not covered under medical insurance policies and Georgia supplemental has managed to tap onto this market by providing policies for large expenses which are not covered by traditional insurance selling companies. The research conducted n 2003 by Benefits Research Inc. stated that an average family spent just about $500 on dental expenses and only about 29 percent of these expenses was focused on preventive care. Similarly, it was found that only 17 percent of the employers’ n Florida were offering their employees with vision care which is a main product and service provided by the Georgia Supplement. This also shows room for a prospective market which can be captured by the company if it decides to expand into Florida. Conclusively, according to the information provided in the case it is a very prospective and fruitful venture for Georgia Supplemental to expand into Florida. The decision of the expansion may be somewhat biased as well as a costly one due to the CEO’s affiliations with the state but the statistics and records show that the market is ripe for the kind of products offered by Georgia and the company expansion would prove to be successful in the coming years. 1. What is your assessment of the proposed direct mail campaign and the promotional letter? Direct mail has already been a successful mode of promotion for financial services and products like credit cards. The assumption in this case is that by using direct mail technique to inform the employers in Florida about the products offered by Georgia the company would be able to promote its product to their future market. This is an appropriate strategy as it tends to drive traffic to the store, generate and increase sales for the company as well as help generate interest and promote the products by promoting brand recognition and cultivating long term relationships with the clients. However, more perseverance is required on the part of the company. It is mentioned in the case that the CEO has contacts in the Florida region. The company can use these contacts as well as the referrals of the satisfied customers in its other markets to build trust and awareness of the company and its products and services in the Florida market. This can be done by sending out promotional letters by direct mail as mentioned in the case. However another more personalized method would be to hold an event or a conference in Florida where the prospective employers and satisfied customers from other markets could be invited, a promotion pitch can be shown to them and the event would also enable the company to build long term business relationships with their prospective clients. This method of promotion would be more expensive than direct mail and likely to drive up the expenses for the company. This method can even support the direct mailing as it would help attract more customers while maintaining the current ones and helping retain them as well. Reference 1.Wolf, K., (1998), Planning a Successful Direct Marketing Campaign, WGSC Publications, available at: http://cpa.utk.edu/pdffiles/adc9.pdf       How to cite Marketing of Financial Services – Georgia Supplemental, Essay examples

Marlene Dietrich, Madonna And The Male Gaze Essays - Feminist Theory

Marlene Dietrich, Madonna And The Male Gaze Marlene Dietrich, Madonna, and the Male Gaze in Blonde Venus and Desperately Seeking for Susan As audiences, we subconsciously identify the male protagonists and take female as spectacle during the film watching, due to the social function of narrative films. (Turner 72)1 Thus feminists have been slashing the objection of female body in male gaze in the narrative films over the decades. Male gaze is in term of the fetishistic scopophilia and sadistic voyeurism. Fetishistic scopophilia deals with male visual control over females for the aesthetic presentation, which influence the presence of female body in films. And sadistic voyeurism is the erotic gaze in pains, which shapes the female characterization in films. Thus, the female characters in narrative films share the common pattern beautiful and fragile, in other words, not intellectual and dependent on men. Nevertheless, Marlene Dietrich in Blonde Venus and Madonna in Desperately Seeking for Susan smash this pattern. They breaks the rule first by being the leading characters in films and such concentration of the female protagonist also means the depiction of male as peripheral to the plot. ( Turner 171)2 Another breaking-rule is their characterization different from the conventional female role. Marlene in the Blonde Venus as Helen Jones is intellectual and capable of mens role of raising a family and Madonnas role, Susan, plays with men, mentioned by Jimmy, Susans boyfriend. But the most alienated from the conventional female role in films is in their way of performing. And even though they all pose some challenge to male gaze, their ways of role-playing are at opposite poles. Their role-playing can discuss from the three elements to shape their characters, camera movement, mise-en-scene and the performance of star. The camera always shoots Marlene from a relative low angle when shes with other male characters. The only two shots shooting her from high angle is when shes questioned by the judge in court and shes gazing her husband for rejoining the family again in the end. Plus those constantly close ups of her face with indifferent eyes all apparently indicates her aloofness and detachment except for her son, while in the Desperately Seeking for Susan most Madonnas shots are packed up with some quick cuts of focus on her spicy body with fire in her eyes for searching something dazzling, like glittering shoes, gold earrings, etc.. While they all appeal to audience in same visual and sensational pleasures, the camera movements create different perspectives for Marlene Dietrich and Madonna. Marlenes high angle shot indicates her relative superior position to male characters and Madonnas body sequences carries one contradictory message, female body freedom or female body spectacle. The crucial reas on is because that Marlene presents it by not looking sexy but being sexy and Madonna does it by looking sexy in dressing less and exposing herself. Though in the opening sequences of the Blonde Venus begins with the naked blondes swimming, what audiences enjoy watching is not the stripped body itself but the way it is presented. The art is in seeming. This pattern carries tremendous pleasures through the Blonde Venus, we appreciate Marlenes legs from the perspective of identifying with the sense of beauty rather than actual sexually desire. Marlene is positioned as a sexual subject rather than sex object in the Blonde Venus. Audiences expect to see whats she going to do or what happen to her next not which part of her body shes going to expose. Shes being viewed and identified as sexy figure not a spectacle of sex. Mise-en-scene is also important for Marlene Dietrichs role-playing, especially costumes. Marlenes cross-dressed figure is constantly showed in the films. Whether with top hats and tails moving her long cigarette holder, taking one dancing girl by the sleeve and pinching her on the cheek in a parody of phallic power (Kaplan126)3 and with fur-trimmed coat and stiletto heels in the conventional codes of female roles (Turner 81)4 work together for her cross-gender representation. And we never see Marlene shake her hips during the show time like what the other dancing girls do in film. When we see her performs on stage, she appears in gorilla suit singing Hot Voodoo or in males